Drug to Potentially Block AIDS Discovered

Sandra Chiefe

Moderator
The precise chain of molecular events in the human body driving the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS has been identified by a scientist at the Gladstone Institutes, in addition to an anti-inflammatory drug blocks the death of these cells as seen during laboratory tests.
According to Vanguard News, the scientists are also undergoing plans to conduct a Phase 2 clinical trial to determine if this drug or a similar drug can prevent HIV-infected people from developing AIDS.

In his lab science paper, Dr. Warner C. Greene reveals that during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells, triggering the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death. This ultimately destroys the immune system, causing AIDS.
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