Pep Guardiola is in desperate need of a victory in order to close the gap on leaders to Chelsea to seven points, while the Gunners will be looking to bounce back from Tuesday's surprise defeat at Everton.
Manchester City starting XI: Bravo, Kolarov, Zabaleta (c), Otamendi, Clichy, Fernando, Sterling, De Bruyne, Sané, Silva, Toure
City Subs: Caballero, Sagna, Stones, Nolito, Navas, Iheanacho, A Garcia
Arsenal starting XI: Cech, Bellerin, Gabriel, Koscielny, Monreal, Coquelin, Xhaka, Walcott, Ozil, Iwobi, Alexis
Arsenal subs: Gibbs, Lucas Perez, Giroud, Ospina, Oxlade-Chamberlain, Holding, Elneny
Manchester City starting XI: Bravo, Kolarov, Zabaleta (c), Otamendi, Clichy, Fernando, Sterling, De Bruyne, Sané, Silva, Toure
City Subs: Caballero, Sagna, Stones, Nolito, Navas, Iheanacho, A Garcia
Arsenal starting XI: Cech, Bellerin, Gabriel, Koscielny, Monreal, Coquelin, Xhaka, Walcott, Ozil, Iwobi, Alexis
Arsenal subs: Gibbs, Lucas Perez, Giroud, Ospina, Oxlade-Chamberlain, Holding, Elneny